SELECT 
  product_id, 
  short_description, 
  full_description 
FROM 
  q_product_descriptions 
WHERE 
  product_id IN (
    300, 301, 302, 303, 304, 305, 306, 307, 
    246, 247, 248, 249, 250, 251, 252, 253
  ) 
  AND lang_code = 'en'

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "38.41"
    },
    "table": {
      "table_name": "q_product_descriptions",
      "access_type": "range",
      "possible_keys": [
        "PRIMARY",
        "product_id"
      ],
      "key": "PRIMARY",
      "used_key_parts": [
        "product_id",
        "lang_code"
      ],
      "key_length": "9",
      "rows_examined_per_scan": 16,
      "rows_produced_per_join": 16,
      "filtered": "100.00",
      "index_condition": "((`portal`.`q_product_descriptions`.`product_id` in (300,301,302,303,304,305,306,307,246,247,248,249,250,251,252,253)) and (`portal`.`q_product_descriptions`.`lang_code` = 'en'))",
      "cost_info": {
        "read_cost": "35.21",
        "eval_cost": "3.20",
        "prefix_cost": "38.41",
        "data_read_per_join": "61K"
      },
      "used_columns": [
        "product_id",
        "lang_code",
        "short_description",
        "full_description"
      ]
    }
  }
}