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SELECT 
  1 
FROM 
  q_lock_keys 
WHERE 
  key_id = '642def1291de8b4b62007e516ab898297cede9bf8bcf9cf0452b9bf8428165b0' 
  AND token = 'TDxxSG31dDrTJGiY+8UpO4QOI39NKSnvBzefZLLTBM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00067

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}