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SELECT 
  1 
FROM 
  q_lock_keys 
WHERE 
  key_id = '49abbd05dd640bacc4737ec69bb0b862e2e5a462a627e496ec015a578a15334c' 
  AND token = 'rchm9bo0NrORfgbAvCOGOug/+x+ct0uNlngB/ULuZnk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}