SELECT 
  q_product_prices.product_id, 
  MIN(
    IF(
      q_product_prices.percentage_discount = 0, 
      q_product_prices.price, 
      q_product_prices.price - (
        q_product_prices.price * q_product_prices.percentage_discount
      )/ 100
    )
  ) AS price 
FROM 
  q_product_prices 
WHERE 
  q_product_prices.product_id IN (
    8653, 8654, 8655, 8656, 8657, 8658, 8659, 
    8660, 8661, 8203, 8204, 8205, 8207, 
    8208, 8209, 8210
  ) 
  AND q_product_prices.lower_limit = 1 
  AND q_product_prices.usergroup_id IN (0, 1) 
GROUP BY 
  q_product_prices.product_id

Query time 0.00086

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "38.41"
    },
    "grouping_operation": {
      "using_filesort": false,
      "table": {
        "table_name": "q_product_prices",
        "access_type": "range",
        "possible_keys": [
          "usergroup",
          "product_id",
          "lower_limit",
          "usergroup_id"
        ],
        "key": "product_id",
        "used_key_parts": [
          "product_id"
        ],
        "key_length": "3",
        "rows_examined_per_scan": 16,
        "rows_produced_per_join": 3,
        "filtered": "19.99",
        "index_condition": "(`portal`.`q_product_prices`.`product_id` in (8653,8654,8655,8656,8657,8658,8659,8660,8661,8203,8204,8205,8207,8208,8209,8210))",
        "cost_info": {
          "read_cost": "37.77",
          "eval_cost": "0.64",
          "prefix_cost": "38.41",
          "data_read_per_join": "76"
        },
        "used_columns": [
          "product_id",
          "price",
          "percentage_discount",
          "lower_limit",
          "usergroup_id"
        ],
        "attached_condition": "((`portal`.`q_product_prices`.`lower_limit` = 1) and (`portal`.`q_product_prices`.`usergroup_id` in (0,1)))"
      }
    }
  }
}

Result

product_id price
8203 135.000000
8204 130.000000
8205 60.000000
8207 32.000000
8208 95.000000
8209 95.000000
8210 95.000000
8653 109.000000
8654 109.000000
8655 109.000000
8656 109.000000
8657 109.000000
8658 69.000000
8659 69.000000
8660 109.000000
8661 169.000000