SELECT 
  q_product_prices.product_id, 
  MIN(
    IF(
      q_product_prices.percentage_discount = 0, 
      q_product_prices.price, 
      q_product_prices.price - (
        q_product_prices.price * q_product_prices.percentage_discount
      )/ 100
    )
  ) AS price 
FROM 
  q_product_prices 
WHERE 
  q_product_prices.product_id IN (
    16250, 16253, 16257, 16259, 16260, 16263, 
    16266, 16267, 16268, 16269, 16270, 
    16271, 16274, 16275, 16295, 16296, 
    16299, 16300, 16302, 16303, 16304, 
    16305, 16306, 16310, 16311, 16312, 
    16313, 16314, 16315, 16316
  ) 
  AND q_product_prices.lower_limit = 1 
  AND q_product_prices.usergroup_id IN (0, 1) 
GROUP BY 
  q_product_prices.product_id

Query time 0.00079

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "72.01"
    },
    "grouping_operation": {
      "using_filesort": false,
      "table": {
        "table_name": "q_product_prices",
        "access_type": "range",
        "possible_keys": [
          "usergroup",
          "product_id",
          "lower_limit",
          "usergroup_id"
        ],
        "key": "product_id",
        "used_key_parts": [
          "product_id"
        ],
        "key_length": "3",
        "rows_examined_per_scan": 30,
        "rows_produced_per_join": 5,
        "filtered": "19.99",
        "index_condition": "(`portal`.`q_product_prices`.`product_id` in (16250,16253,16257,16259,16260,16263,16266,16267,16268,16269,16270,16271,16274,16275,16295,16296,16299,16300,16302,16303,16304,16305,16306,16310,16311,16312,16313,16314,16315,16316))",
        "cost_info": {
          "read_cost": "70.81",
          "eval_cost": "1.20",
          "prefix_cost": "72.01",
          "data_read_per_join": "143"
        },
        "used_columns": [
          "product_id",
          "price",
          "percentage_discount",
          "lower_limit",
          "usergroup_id"
        ],
        "attached_condition": "((`portal`.`q_product_prices`.`lower_limit` = 1) and (`portal`.`q_product_prices`.`usergroup_id` in (0,1)))"
      }
    }
  }
}